In 1862, the historical fortunes of the old Palazzo Lozzano drew to a close, marking the beginning of the reconstruction work that would culminate in the current building. The work was entrusted to the architect Antonio Sarti, who had already been involved in building the original Palazzo Lozzano in 1832. Sarti transformed the building significantly, and the new, elegant "Albergo di Roma" was born in the place of the Palazzo Lozzano.
Architect Sarti initially planned to extend the original façade to cover a large part of the street. However, the project underwent a number of changes during its realisation, and in 1864 the "Albergo di Roma" was opened for business, maintaining its largely unchanged form for the next forty years.