More recently, the Grand Hotel Plaza has served as the backdrop for major international productions. The interior of the hotel was chosen for films such as Ocean's 12, starring Brad Pitt and George Clooney, and Martin Scorsese's Gangs of New York. The film Along Came Polly, with Jennifer Aniston and Ben Stiller, used the Plaza as a location, as well as the sequel to John Wick, with Keanu Reeves. Gabriele Muccino's latest film, I migliori anni, released in February 2020, staged some of its most significant scenes at the Grand Hotel Plaza, telling the story of Italy from 1982 to the present day through an exceptional cast that includes Pierfrancesco Favino, Kim Rossi Stuart and Claudio Santamaria.